SPSB1 and Sepsis: Sepsis caused a reduction in body (control_shRNA: −23%, P < 0.001; Spsb1_shRNA: −9%, P = 0.3), TA (−26%, P < 0.01) and GP (−21%, P < 0.01) weights, which was reduced by Spsb1 knockdown (Figure S18C).