A similar result was also demonstrated in a study done in Turkey, decreasing LCR with the disease severity.6 This is similar to the result of a meta-analysis done in Mexico demonstrating that the LCR was decreased in severe cases.13 These lower LCR levels in severe patients could be the result of fewer lymphocytes leading to immune dysfunction and higher CRP levels reflecting the severe systemic inflammatory response of the patients. This evidence concerns the gene CRP and immune system disorder.