However, our further analysis of the AP parameters revealed that CRS increased the input resistance while decreased the rheobase and sag ratio in BLA-projecting dmPFC neurons, hinting a potential involvement of HCN channels, which have been widely reported in regulating the input resistance and sag ratio, and subsequently modulates neuronal excitability [36, 53–55], and are considered as a potential target for treating stress-related disorders, such as anxiety and depression [56, 57]. This evidence concerns the gene MALAT1 and depressive disorder.