Furthermore, PBA treatment uniquely induced expression of FAM162A and DUSP6, and FAM162A mediates mitochondrial apoptosis in prostatic and lung adenocarcinoma cells [49, 50], while DUSP6 is a transcriptional target of p53 and regulates p53-mediated apoptosis by dephosphorylating Bcl-2 proteins [51]. The gene discussed is TP53; the disease is lung adenocarcinoma.