SLC7A11 and glioma: However, another study showed that, the overexpression of SLC7A11 induces DNA double-strand break (DSB) and enhances the sensitivity of GBM cells to radiotherapy [69]. According to the TCGA data, while the SLC7A11 gene is highly expressed in GBM patients, it has a negative correlation with glioma WHO grades and the patients’ prognosis.