Compared with primary GBM tissues, high SRY-Box transcription factor 3 (SOX3) expression was detected in recurrent GBM tissues, and the exogenous overexpression of SOX3 in GBM cells can enhance the activity of Hh signaling and inhibit cytotoxic autophagy, increasing migration and invasion capabilities [169]. This evidence concerns the gene SOX3 and glioblastoma.