These cells have high levels of perforin and Granzyme B (Gzm B), and with the help of perforin, Gzm B can be delivered into cancer cells directly or indirectly, via coordinating with caspase-3, cleave the identical amino acid site D270 of the N-terminal domain of GSDME, activating pyroptosis. This evidence concerns the gene CASP3 and cancer.