ANXA2 and cancer: The CAF-derived sEV lncC01614 mediates enhanced glutamine absorption in cancer cells by interacting with ANXA2 and p65 to promote ANXA2-dependent p65 phosphorylation, which, in turn, activates the NF-κB pathway to increase glutamine transporters SLC38A2 and SLC7A5, ultimately enhancing the inflow of glutamine into tumor cells [48].