Mechanistically, sEV-packaged HIF-1α-stabilizing lncRNA (HISLA) suppresses the function of PHD2 to block the degradation of HIF-1α, whose expression is positively related with the expression levels of GLUT1, GLUT3 and HK2, thus allowing the ability of cancer cells to metabolize glucose in a condition without oxygen to survive for an extended period of time [16]. Here, HK2 is linked to cancer.