Besides, circPDK1 functioned as a frame to promote the binding of BIN1 proteins (a tumor suppressor limiting c-Myc transcriptional activity) and UBE2O (a ubiquitin-conjugating enzyme), enhancing the effects of UBE2O on ubiquitin-dependent degradation of BIN1 and increasing c-Myc transcriptional activity eventually. The gene discussed is UBE2O; the disease is neoplasm.