In contrast, a lower EC50 was observed in PRLRint AML cells (MonoMac-1), as compared to PRLRlow AML cells (HL-60), when challenged with the Stat5 (30 μM vs. 213 μM) inhibitor (Fig. 4E and Additional file 1: Fig. S3C). The gene discussed is STAT5A; the disease is acute myeloid leukemia.