In concordance with this preliminary analysis and previous reports [12], PRLR mRNA was differentially expressed in AML (2.544 ± 0.066) samples as compared to healthy blood donors (2.053 ± 0.174), whereas no significant differences were found in the natural ligand PRL gene expression, at an autocrine level (Fig. 1A). The gene discussed is PRLR; the disease is acute myeloid leukemia.