While enforced expression of PRL in AML cells failed to confer chemoresistance to cytarabine, overexpression of PRLR significantly augmented the EC50 of cytarabine in AML cells (Fig. 5C), suggesting that the PRLR-mediated signaling was responsible for overcoming the cytotoxicity effect produced by cytarabine. Here, PRL is linked to acute myeloid leukemia.