PRL and leukemia: Whereas the leukemic repopulation capacity of AML remained unaffected by the enforced expression of PRL wt or PRLR wt, PRL-neglected signaling AML cells (PRL mut or PRLR short) consistently underperformed, both in bone marrow and spleen (Fig. 3E), supporting the role of PRLR-mediated signaling in the leukemia engraftment potential in vivo.