Regarding clinical manifestations, our study revealed that the most common cutaneous manifestations were malar rashes (77.8%), ulcerations (56.7%), alopecia (40%), discoid lesions (20%), and photosensitivity (61.1%), with no significant difference between subgroups except for a significantly higher frequency of discoid lesions in the AQP4-IgG Ab-positive subgroup than in the AQP4-IgG Ab-negative subgroup (p = 0.039). The gene discussed is AQP4; the disease is alopecia.