KCNJ16 expression change might come from DNA methylation, cause its expression in thyroid cancer was negatively correlated with DNA promoter methylation and CpG hypermethylation appeared in metastatic group and thyroid papillary carcinoma - tall cell ( > = 50% tall cell features) (Additional Fig. 1A and B). This evidence concerns the gene KCNJ16 and thyroid gland papillary carcinoma.