KCNJ16 expression change might come from DNA methylation, cause its expression in thyroid cancer was negatively correlated with DNA promoter methylation and CpG hypermethylation appeared in metastatic group and thyroid papillary carcinoma - tall cell ( > = 50% tall cell features) (Additional Fig. 1A and B). Here, KCNJ16 is linked to differentiated thyroid carcinoma.