To assess the ability of the TRscore to independently predict TACE prognosis compared with traditional clinical features, including sex, age, ALT, tumor size, tumor number, TNM stage, and AFP metrics, we used the GSE14520 cohort within the HCC-TACE cohort with univariate and multivariate Cox regression analyses performed on these variables for 99 samples with complete clinical information. This evidence concerns the gene AFP and hepatocellular carcinoma.