The results showed that CYP3A4, DKK1, AASS, NDRG1, CD5 L, ADH1B, SULT2A1, DCXR, ANXA10, CES2, KLKB1 and ADH1A were the key influencing factors of TACE response in HCC, of which NDRG1 and DKK1 were risk factors for TACE response (Fig. 6A, B). This evidence concerns the gene CD5L and hepatocellular carcinoma.