TNF and allergic disease: CMP can improve the immunity of mice by regulating TNF signaling pathway and increasing the number of white blood cells, the degree of delayed allergy and the content of hemolysin in the serum [41].BS-Z15 secondary metabolite treatment increased the number of platelets and monocytes in the blood of mice, significantly enhanced the function of monocytes-macrophages and NK cells, increased the level of tumor necrosis factor and activated the tumor necrosis factor signaling pathway to regulate the intrinsic immune function of mice.