CD8A and neoplasm: In addition, NK cells perform immunosurveillance functions in the absence of antigenic stimuli and antibodies, directly lysing and removing tumor cells and virus-infected cells [35].CCL3 also initiates the differentiation of progenitor T cells to CD4+ T cells and CD8+ T cells [36], and the recruitment of DCs and T cells increases the chance of encounters between antigen-specific T cells and professional antigen-presenting cells (pAPC), thereby regulating the adaptive immune response in mice [37].