IL1B and chronic hepatitis B virus infection: The expression of IL-1β in Group B was comparatively lower than that in the early non-response group at 0w, possibly due to the high viral load, elevated expression of HBV-related proteins, and the presence of HBsAg > 3000IU/mL, HBeAg (+), and HBV-DNA (+) in patients with chronic hepatitis B (CHB), which may result in an elevated baseline IL-1β expression.