The top reason physicians said they prescribed orlistat (91%), SGLT2 inhibitors (70%), GLP-1 RAs (67%), pioglitazone (56%), DPP4 inhibitors (55%), metformin (46%), and vitamin E (40%) was to assist with weight loss; the second most common reason to prescribe these medications was to improve/reverse steatosis. The gene discussed is DPP4; the disease is steatosis.