OpenWAS replication in the FinnGen cohort confirmed the associations between LDL lowering and hypercholesterolaemia, using the HMGCR genetic instrument and between LDL lowering and hypercholesterolaemia, hyperlipidaemia and unstable angina pectoris, using the LDLR genetic instrument (Table S9). The gene discussed is LDLR; the disease is Hypercholesterolemia.