TNFRSF11B and fatty liver disease: In addition, OPG seems to affect hepatic steatosis, as its overexpression triggers the signal-regulated kinase (ERK)-peroxisome proliferator-activated receptor-γ (PPAR-γ)-cluster of differentiation (CD36) pathway and, therefore, resulted in increased hepatic lipid accumulation, highlighting the potential pleiotropic effects of OPG in liver disease [88].