TNFSF11 and metabolic dysfunction-associated steatohepatitis: In line, another group reported that HFD caused a gradual increase in circulating RANKL levels and hepatic RANKL expression from controls to mice with simple nonalcoholic fatty liver (NAFL) and then to mice with nonalcoholic steatohepatitis (NASH), regarded as a more severe than NAFL phenotype of the disease [84].