Additionally, TNF-α, IL-1, and LPS have been shown to induce OPG production by pancreatic β-cells, which, in turn, restricts insulin secretion and improves their survival [42]; this may mean that OPG targets to protect the survival of β-cells with the cost of hypoinsulinemia under inflammatory circumstances, an hypothesis that may warrant further research. The gene discussed is TNFRSF11B; the disease is Hypoinsulinemia.