Patients who died or underwent LT usually had lower hemoglobin (HGB), platelet (PLT), TC, and AFP levels, worse indices of ALB, AST, INR, TBIL, ammonia, serum creatinine, disease severity scores (MELD, KCC for non-APAP, and ALFSG-PI) and more clinically detectable complications (ascites, infection, AKI, and high-grade (III–IV) HE than TFS patients (p < 0.05 for all). The gene discussed is AFP; the disease is hereditary elliptocytosis.