Wang et al. compared the concentrations of 10 chemokines and chemokine receptors (CXCL5, 7, 8, 12, CCL2, CXCR4, CCR2, 5, 7 and atypical chemokine receptor DARC/ACKR1) in the serum of 148 patients diagnosed with benign breast changes, epithelial proliferation (present only or with atypia), in situ carcinoma and invasive carcinoma. This evidence concerns the gene ACKR1 and invasive carcinoma.