CCR2 and neoplasm: Infiltration of Ly6Chigh monocytes was reduced by 3- to 7-fold in all models; however, a significant reduction (more than 2-fold change) in tumor-infiltrating macrophages (TIMs) (CD11b+Ly6G−Ly6C−F4/80+) was observed only in MES tumors, indicating that CCR2 dependency was MES specific.