Extracellular DNA uptake and the activation of inflammasomes are restrained by T-cell immunoglobulin and mucin-containing molecule 3 (TIM-3) on DCs, suggesting a novel mechanism for TIM-3 inhibitors.74,75 After specifically knocking out TIM-3 in DCs, tumor growth was significantly inhibited in mouse models, and this effect was stronger than that of knocking out TIM-3 in T cells.74 The synergistic effects of RT+anti-TIM-3 have not been ideal. The gene discussed is HAVCR2; the disease is neoplasm.