PDCD1 and glioblastoma: Intriguingly, it was shown that LDRT (2 Gy) promoted M1 repolarization, reduced PD-1 expression and enhanced TAM phagocytosis.1,96 Although repolarization can be mediated by exosomes containing a higher level of HMGB1 produced by irradiated cells, the underlying mechanism is still unclear.96,97 Soluble intercellular adhesion molecule-1 (sICAM-1) produced by GBM cells after RT contributes to the infiltration of macrophages.