sTAMs exhibiting M1-like macrophage phenotypes are thought to have an antitumor effect, while pTAMs exhibiting M2-like macrophage phenotypes are considered tumor-promoting.90 The polarization of M1-like macrophages requires stimuli such as IFN-γ produced by NK cells and Th1 cells, or TLR ligands such as lipopolysaccharide (LPS). The gene discussed is IFNG; the disease is neoplasm.