STING agonists are useful for achieving M1 polarization, especially in BRCA1-deficient breast cancer, which features more M2 polarization.103 ADI-PEG20, an inhibitor of Arg1, was shown to be effective in an arginosuccinate synthetase 1 (ASS1)-negative GBM tumor model. The gene discussed is ARG1; the disease is neoplasm.