RLRs are composed of RIG-I, melanoma differentiation-associated protein 5 (MDA5), and laboratory of genetics and physiology 2 (LGP2).77 The gene expression of LGP2 and MDA5 has been found to be associated with DC enrichment.78 LGP2 was reported to be linked with CD8+ T cell survival in antiviral responses79; later, LGP2 was found to be essential for the antitumor effects of RT because LGP2-deficient BMDCs cannot cross-prime T cells since IFNβ induction in response to irradiated tumor cells is greatly impaired. This evidence concerns the gene DHX58 and neoplasm.