They are derived from DC1s and DC2s, and their differentiation is associated with the uptake of tumor antigens by DC1s and DC2s.63 It was found that the PGE2-EP2/EP4 pathway can activate NF-κB gene transcription to promote mregDCs to recruit regulatory T cells (Tregs), but the mechanism by which mregDCs change after RT still needs to be elucidated.64 Here, NFKB1 is linked to neoplasm.