The term tumor-associated neutrophils (TANs) specifically refers to blood neutrophils attracted into the TME not only by CXCL1, CXCL2, CXCL6, and CXCL8 expressed by tumor cells but also by IL-17 expressed by γδT cells.145 Similar to TAMs, TANs can be divided into two phenotypes: the antitumor phenotype (N1) and the N2.146 The conversion between N1 and N2 depends on cytokines in the TME. This evidence concerns the gene CXCL8 and neoplasm.