The NF-κB transcription factor RelA was essential for CXCL8 release from irradiated tumor cells, which caused CD56dim rather than CD56bright NK cells to migrate to the tumor.196 In addition, RT was also found to activate the mTOR pathway to reduce the expression of IκB-α, an NF-κB inhibitory protein, to promote CXCL8 release.196 However, the function of NK cells is limited. This evidence concerns the gene NFKBIA and neoplasm.