CXCL2 and neoplasm: RT can induce sterile inflammation, characterized by the infiltration of neutrophils.152 Radiation to healthy lung tissues creates a pro-metastatic microenvironment by increasing neutrophil infiltration and promoting neutrophil degranulation.149 Comparatively, radiation to tumor cells causes persistent DNA damage, whereby dying cancer cells release chemoattractants such as CXCL1, CXCL2, and CCL5 to recruit neutrophils.