CSF3 and neoplasm: By lowering the level of plasma granulocyte colony-stimulating factor (G-CSF), BART also restrained tumor metastasis because G-CSF causes PMN-MDSCs to accumulate in the lungs, leading to the formation of the lung premetastatic niche.140 The median survival of the 4T1 mouse model was further increased when the mice were treated with BART plus M3814, which suppressed the repair of DSBs.30