Caspase 8 acts as a converter to cause cancer cells undergoing necroptosis to shift to undergo apoptosis, and only cells undergoing necroptosis can produce type I IFN, which is essential for maintaining the inflammatory irradiated TME and activating the subsequent immune response.40 The DNA exonuclease Trex1 produced by cancer cells after high-dose radiotherapy (HDRT, 12–18 Gy) can degrade cytosolic DNA in both cancer cells and RT-TEX, indicating that Trex1 can lead to less activation of DCs, thereby reducing the effects of RT. This evidence concerns the gene CASP8 and cancer.