We previously showed that Yes-Associated Protein (YAP) drives Y-box binding protein 1 (YB1) activity, resulting in Insulin-like growth factor 2 (IGF-2) promoter binding and an autocrine feedback loop which promotes proliferation of cerebellar granular neural precursors (CGNPs) and NeuroD2-SmoA1-derived primary SHH mouse medulloblastoma cells (referred to as MBCs)5. This evidence concerns the gene IGF2 and medulloblastoma.