SOCS6 and neoplasm: While both the SSI4 treatment group and SSI4 + 5FU + CDDP combination treatment group resulted in a similar reduction in tumor volume, tumor weight and relative tumor growth (Fig. 5d-f), we did note that the tumor-initiating cell frequency which marks self-renewal was significantly more abrogated in the combination group as compared to the SSI4 treatment group alone (Fig. 5g).