Similar implications should be considered with the various bispecific agents that target cluster of differentiation3 (CD3) and either b cell maturation antigen (BCMA) or G-protein coupled receptor family C group 5 member D (GPRC5D) among others, which have also been shown to be associated with increased risk for CRS, with however no reported cardiac failure thus far [47, 48]. Here, TNFRSF17 is linked to congenital rubella syndrome.