Considering that cortical brain areas are differently affected by amyloid β and tau pathologies, and that vascular changes are intimately related to AD, the goals of this work were twofold: (1) to characterize baseline heterogeneity in the endothelial cell transcriptome in the normal aged brain; and (2) to elucidate how regional differences in disease progression impact endothelial cell gene expression in AD. This evidence concerns the gene MAPT and Alzheimer disease.