CD274 and neoplasm: T cells are regulated by the programmed cell death protein-1 (PD-1)/programmed death ligand-1 (PD-L1) pathway and other immune checkpoints.8 9 Despite its inherent inhibitory effect on CD8+T cells, an active PD-1/PD-L1 pathway may correlate with an activated immune response and an improved prognosis among aggressive subtypes.10 Assessments of the PD-1/PD-L1 axis provide independent information in addition to tumor-infiltrating lymphocytes (TILs),11 but it is unknown if this can be used to improve RT individualization.