Interestingly, in a manner similar to the regulation of lipoprotein secretion by FABP1 (159), FABP5 is reported to regulate ER to Golgi trafficking of large coat protein complex II (COPII)-coated vesicles by binding to the vesicle trafficking protein complex and modulating the GTPase activity of SAR1, as shown using cell-free vesicle trafficking analysis with subcellular components from a hepatoma cell line (122). This evidence concerns the gene FABP1 and hepatocellular carcinoma.