The RNF43-, CYP2S1- and LIF-related super-enhancers are shown as colorectal cancer–specific super-enhancers since the odds ratio of these three gene-related super-enhancers are >20 (P < 0.05) in primary tissues and >15 in cell lines (P < 0.05) (Figure 3C). This evidence concerns the gene LIF and colorectal cancer.