This GrimAge is not only associated with blood glucose-, insulin-, and triglyceride levels, anthropometric measures of adiposity (i.e., body mass index and waist-to-hip ratio), and hypertension and type 2 diabetes status, but also highly predictive of lifespan and incident cardiovascular disease, which outperforms the other three established DNAmAges [31]. The gene discussed is INS; the disease is Hypertension.