Interestingly, Toll-like receptor 2 expression in the substantia nigra of Parkinson’s disease patients was significantly higher than in healthy controls but significantly lower than in sporadic Lewy body disease (132) (prodromal phase of Parkinson’s disease and asymptomatic phase), thus supporting Toll-like receptor 2 expression in the early disease process. Here, TLR2 is linked to Parkinson disease.