TLR2 and Parkinson disease: In addition, this study reports an association between Toll-like receptor 2 expression in the substantia nigra striatum and occasional microglia initiated in Lewy body disease, leading the authors to suggest that upregulation of Toll-like receptor 2 may represent widespread Parkinson’s disease pathology and neurodegeneration and that this early microglial activation may be due to interactions between Toll-like receptor 2 and oligomeric α-synuclein (132).