To evaluate the combined effect of COMP and tumor fibrosis on the infiltrating immune cells, we stratified the patients into four groups: 1) low collagen density and low COMP expression in stroma (collagen-COMP low stroma), 2) high collagen density and high COMP expression in stroma (collagen-COMP high stroma), 3) low collagen density and low COMP expression from cells (collagen-COMP low cells), 4) high collagen density and high COMP expression in cells (collagen-COMP high cells). Here, COMP is linked to neoplasm.