In multivariable Cox proportional hazards analyses, COMP expression in the cancer cells (p=0.029) and in the stroma (p=0.021) was associated with reduced patient OS with a hazard ratio of 1.2, after adjustment for BRAF and KRAS mutations, tumor differentiation, TNM-stage, and vascular invasion (Figure 2B). The gene discussed is COMP; the disease is neoplasm.