Clinical studies have shown that, as the core component of Mi-2/nucleosome recombination and deacetylase complex (NuRD), LSD1 is involved in the regulation of a variety of signal pathways related to tumor cell growth, metastasis and invasion, such as E-cadherin snail slug EMT pathway and tumor invasion related TGF-β signaling pathway (28). This evidence concerns the gene TGFB1 and neoplasm.