CD4 and neoplasm: We observed significantly down-regulated expression levels of the adhesion molecule CD62L (L-selectin), a known target of MDSCs (38), on CD8 T cells, CD4 T cells, and NK cells in the spleen and DLN of BCG-treated mice at day 7 post tumor transplantation, which were further exacerbated by Traf3 deficiency in myeloid cells (Figures 2F, G, S4A, B).