Kanako Minami and his colleagues found that Free fatty acid receptor 1 (FFA1) and FFA4, which regulate various malignant properties in cancer cells, may play a significant role in the modulation of cellular functions by ECs in OS, with higher expression levels of FFAR1 and FFAR4 genes in highly migratory MG63-CR7(F2) cells than in MG-63 cells, and knockdown of FFA1 or FFA4 inhibiting cell survival in the presence of cisplatin (30). This evidence concerns the gene FFAR1 and cancer.