Also, FDXR and CPT1A did not correlated in the ER+ breast cancer patients (Supplementary Figures 7A–C; Supplementary Table 8), the reason could be that both CPT1A and mitochondrial OXPHOS genes were downstream genes regulated by FDXR, and also other factors may co-regulate CPT1A expression. The gene discussed is ESR1; the disease is breast cancer.