In this study, we analyzed the correlation between MINDY2 in PC and immunity and found that MINDY2 was significantly and positively correlated with infiltration scores of B cells, T cells CD8+, neutrophil, macrophage, and myeloid dendritic cells in PC, and although there was no statistical significance between MINDY2 and T cells CD4+, it can be concluded that the expression level of CD4+ T cells was greater in the MINDY2 high expression group than in the low expression group. The gene discussed is CD8A; the disease is pachyonychia congenita.