ACTN4 and cancer: To further clarify the role of ACTN4 in the cancer-promoting process of MINDY2, after we down-regulated ACTN4 and upregulated MINDY2 co-treated BxPC-3 cells, the results of CCK-8, clonal plate, and EdU experiments suggested that the function of MINDY2 in enhancing PC cell viability and proliferation ability was reversed (Figures 7A–C).