>20% of patients with MTC (N=319): dry mouth (36%), hypertension (32%), fatigue (35%), oedema (34%), diarrhoea (25%), increased aspartate aminotransferase level (26%); increased alanine aminotransferase level (25%); constipation (21%); Grade 3+ (>5%): hypertension (14%), increased alanine aminotransferase level (7%), increased aspartate aminotransferase level (6%). The gene discussed is GPT; the disease is hypertensive disorder.