Also of note is a similar trend shown by CA9 (hypoxia) and MKi67 (proliferation), which could be indicative that the fast growth of the tumour in these previously untreated patients is not being supported at the same rate by the formation of new tumour neo-vascularisation, resulting in apoptosis triggered by hypoxia (45), and for CD8-related phenotypes. The gene discussed is CA9; the disease is neoplasm.