CASP8 and Huntington disease: Target prediction, followed by reactome pathway enrichment analysis, revealed several target genes involved in pathways related to brain physiopathology (Table 1), Caspase-8 (CASP8) and Fas-associated protein with death domain (FADD) like apoptosis regulator (CFLAR) in “CASP8 activity” (Strand et al., 2005) and Neural precursor cell expressed developmentally downregulated gene 4-like (NEDD4L) in “Downregulation of TGF-beta receptor signaling/Downregulation of SMAD2/3:SMAD4 transcriptional activity” (Ding et al., 2013), suggesting a possible role of the brain piRNAs in HD pathogenicity.