MAPT and Alzheimer disease: Patients with AD exhibit some pathological symptoms, including amyloid plaques, which are mainly composed of aggregates of amyloid beta (Aβ) peptides, and neurofibrillary tangles (NFTs), composed of hyperphosphorylated tau filaments that are further linked with neurodegenerative tauopathies and synaptic loss in the brain (McKhann et al., 1984; Braak and Braak, 1990, 1991, 1996; Serrano-Pozo et al., 2011; DeTure and Dickson, 2019).