We also observed binding of HIF-2α in HKC-8, RCC4 and 786-0 cells in the published ChIP-seq data and wondered whether this isoform could contribute to PKD1 regulation under certain circumstances, e.g. in renal cancer, when HIF-2α is released by defective VHL protein (electronic supplementary material, figure S3a). Here, EPAS1 is linked to renal carcinoma.