PPARG and pulmonary fibrosis: In this regard, recent evidence from studies on animal models of liver and lung fibrosis has highlighted that activated myofibroblasts may undergo a dedifferentiation process by switching toward a quiescent lipofibroblast phenotype when fibrosis resolution occurs, through the activation of PPARγ signaling (Kisseleva et al., 2012; El Agha et al., 2017b; Kheirollahi et al., 2019).