Moreover, a study by Sullivan-Gunn and Lewandowski (8) has highlighted the role of NOX2 enzyme in a healthy mouse model of aging, suggesting that elevated levels of H2O2 from NOX2, as well as the lack of antioxidant protection from catalase and glutathione peroxidase (GPX), carry out a key role in the onset of sarcopenia. This evidence concerns the gene CYBB and sarcopenia.