However, it is worth mentioning that HP colonization of nasal polyps in patients with GERD may probably support a reservoir thesis similar to other extragastric sites, because many studies have suggested that gastroesophageal and laryngopharyngeal reflux are linked to nasal disorders and may contribute to chronic rhinosinusitis development via gastric acid exposure and triggering inflammation pathways [24]. This evidence concerns the gene HP and chronic rhinosinusitis.