Recently, aberrant or sustained cGAS/STING activation has been observed in a number of neurodegenerative diseases and is thought to contribute to neuronal dysfunction via microglial-induced CNS neuroinflammation and neurodegeneration (Sliter et al., 2018; Yu et al., 2020; Jin et al., 2021; Paul et al., 2021). Here, CGAS is linked to neurodegenerative disease.