In the CNS, excessive or chronic cGAS/STING activation in microglia leads to inflammation and neurodegeneration (Paul et al., 2021; Tanaka and Takahashi, 2021) and is implicated in multiple neurodegenerative diseases, such as ataxia telangiectasia, Parkinson’s disease, amyotrophic lateral sclerosis, and Alzheimer’s disease (Sliter et al., 2018; Yu et al., 2020; Jin et al., 2021; Paul et al., 2021). Here, STING1 is linked to Alzheimer disease.