Hypofractionated RT of 8 Gy × 3f showed the best effect of primary tumor control with the significantly increased infiltration of CD8+ tumor‐infiltrating lymphocytes (TILs) and CD4+ TILs, whereas anti‐PD‐1 alone did not have any effect on either tumor control or immune cell infiltration. The gene discussed is CD4; the disease is neoplasm.