High expression of CD151, EFNB2, COL5A1, ITGA3 or ANAX2 most significantly reduced OS, while high SOX4, CX3CR1, MYB, TCF7L2 and XBP1 expression levels correlated with prolonged “RT” OS in multiple cancer types (TCGA survival analysis source data provided in Table S3). The gene discussed is TCF7L2; the disease is cancer.