We reported that the elevation of C-X-C motif chemokine ligand (CXCL) 9, CXCL10, CXCL11, CXCL13, and interleukin (IL)-21 might be a signature pattern in attaining a functional HBV cure in acute hepatitis B patients and in the chronic hepatitis B patients who were treated with a sequential combination of nucleotide analogues followed by PEG-IFN-α (10). The gene discussed is CXCL11; the disease is chronic hepatitis B virus infection.