EIF2AK3 and Alzheimer disease: Lifetime substance abuse diagnoses were significantly associated with worse depressed mood (mean±SD, 11.2±10.0 versus 7.25±8.00, p=0.0006) and with PERK haplotype (AB 81.1%, AA 78.2%, AD 55.7%, BB 64.3%, BD 100%, 0.0380).