Hence, we speculate that the rates of CRC are lower in premenopausal women (8, 9, 44) due to higher ERβ (14, 33, 35) and PGR (30, 52) alongside lower ERα (47–49) and AR (56, 58) expression in colonic tissues, whereas their pathological alterations following menopause might trigger CRC. Here, ESR1 is linked to colorectal carcinoma.