With the increase in clinical pathological stage (Figures 2B1–3), T-stage (Figures 2D1–3), N-stage (Figures 2E1–3), vascular invasion (Figures 2F1–3), and perineural invasion (Figures 2G1–3); the decrease in tumor tissue differentiation (Figures 2C1–3), the CD4+ T-lymphocyte content and the CD4+/CD8+ ratio significantly decreased, while the CD8+ T-lymphocyte content significantly increased. Here, CD8A is linked to neoplasm.