In their study they found that naive CD8+ T cells targeting tumor antigens are first initiated in peripheral lymphoid tissues to generate stem cell-like PD-1loCD8+ T cells with self-renewal properties, which migrate toward TME and form immune-responsive PD-1loCD8+ T cells in response to chemokines CCL5 and CXCL9. This evidence concerns the gene CXCL9 and neoplasm.