FABP1 and bile reflux: Thus, we established a rat model of GIM by administrating 2% sodium salicylate solution and allowing the rats to freely drink 20 mmol/L sodium deoxycholate solution for 12 weeks; and found that the DCA–Rikenellaceae RC9 gut group–RGD1311575/Fabp1 axis might be the key biological mechanism during the development of bile reflux-induced GIM by integrating the microbiome, transcriptome, and targeted metabolomics of serum BAs.