As KLF4 is known to be an immune marker for dendritic cell differentiation and essential for inflammatory monocyte differentiation [33, 34], our results indicate that putative regulatory elements of immune response-related genes such as IL1RL1, CD274, and CD44 are strongly related to KLF4. However, it should be noted that we did not evaluate the validity of our results using an independent rhinitis cohort, which requires further extended studies in the near future. Here, CD274 is linked to rhinitis.