We found that most of the immune- and cytokine-related signatures were significantly altered between AR1 and AR2 (Figure 2(d)), revealing a gradual increase in the expression of top genes and rhinitis marker genes (e.g., IL1RL1, CD274, and CD44) from healthy controls to AR1 and then AR2 (Figure 2(e)) [19, 20]. This evidence concerns the gene CD274 and rhinitis.