Thus, it is obvious to understand that the British Society for Haematology (BSH) guidelines, the American Society of Haematology (ASH) 2020 guidelines, and the USA National Institutes of Health Expert Panel (NIHEP) recommend prophylactic matching for Rh (C, E or C/c, E/e), and K in addition to ABO and D in patients with SCD [42, 43, 44, 47]. The gene discussed is RHCE; the disease is Schnyder corneal dystrophy.